This symposium serves as the crossroads for process safety where industry, academia, government agencies and other stakeholders come together to discuss critical issues of research in process safety. Experts from around the world will gather as part of this two and a half-day symposium, to share the latest information on the hottest topics aimed at making the process industry a safer place. The symposium “Beyond Regulatory Compliance, Making Safety Second Nature” is scheduled for Oct. 25-27, 2011 at the Hilton Conference Center and will feature wide variety of safety-related lectures and presentations. In addition, the symposium will feature an exhibit area where companies can demonstrate the latest products, technology and software related to process safety.

College Station, Texas Home to Texas A&M University

HamiltonThe Honorable Lee H. Hamilton will present the Frank P. Lees Memorial Lecture on Tuesday, October 25. Hamilton represented Indiana in the U.S. House of Representatives for 34 years, establishing himself as a leading figure on foreign policy, intelligence, and national security. In the years since he left public office in 1999, he has continued to play a leading role in public affairs. Lee Hamilton is director of The Center on Congress at Indiana University, one of the nation’s foremost experts on Congress and representative democracy. He served as vice chairman of the National Commission on Terrorist Attacks Upon the United States, known as the 9/11 Commission. He co-chaired the Iraq Study Group, a bipartisan panel that assessed the situation in Iraq and in 2006 made recommendations on U.S. policy there. Currently he is co-chairman of the U.S. Department of Energy’s Blue Ribbon Commission on America’s Nuclear Future. Among his published works are two books on the legislative branch-How Congress Works and Why You Should Care and Strengthening Congress. He writes twice-monthly commentaries about Congress and what individuals can do to make representative democracy work better. A leader in the growing national movement to expand and improve civic education, he serves as a Co-Chairman of the Campaign for the Civic Mission of Schools.October 26, 2011

CalabreseDr. Edward J. Calabrese is the keynote speaker on day two of the Symposium. Edward Calabrese is a Professor of Toxicology at the University of Massachusetts, School of Public Health, Amherst. Dr. Calabrese’s research includes assessment of hormesis, a dose-response concept that is characterized by low-dose stimulation and a high-dose inhibition. He traces the historical foundations of hormesis, its quantitative features and mechanistic foundations, and its risk assessment implications. It will be argued that the hormetic dose response is the most fundamental dose response, significantly out-competing other leading dose-response models in large-scale, head-to-head evaluations used by regulatory agencies such as the EPA and FDA. The hormetic dose response is highly generalizable, being independent of biological model, endpoint measured, chemical class, physical agent (e.g., radiation) and inter-individual variability. Hormesis also provides a framework for the study and assessment of chemical mixtures, incorporating the concept of additivity and synergism. Because the hormetic biphasic dose response represents a general pattern of biological responsiveness, it is expected that it will become progressively more significant within toxicological evaluation and risk assessment practices as well as having numerous biomedical applications, some of which will be emphasized in this presentation.2011 OFFICIAL SYMPOSIUM SPONSORS:

This symposium serves as the crossroads for process safety where industry, academia, government agencies and other stakeholders come together to discuss critical issues of research in process safety. Experts from around the world will gather as part of this two and a half-day symposium, to share the latest information on the hottest topics aimed at making the process industry a safer place. The symposium “Beyond Regulatory Compliance, Making Safety Second Nature” is scheduled for Oct. 25-27, 2011 at the Hilton Conference Center and will feature wide variety of safety-related lectures and presentations. In addition, the symposium will feature an exhibit area where companies can demonstrate the latest products, technology and software related to process safety.

College Station, Texas Home to Texas A&M University

HamiltonThe Honorable Lee H. Hamilton will present the Frank P. Lees Memorial Lecture on Tuesday, October 25. Hamilton represented Indiana in the U.S. House of Representatives for 34 years, establishing himself as a leading figure on foreign policy, intelligence, and national security. In the years since he left public office in 1999, he has continued to play a leading role in public affairs. Lee Hamilton is director of The Center on Congress at Indiana University, one of the nation’s foremost experts on Congress and representative democracy. He served as vice chairman of the National Commission on Terrorist Attacks Upon the United States, known as the 9/11 Commission. He co-chaired the Iraq Study Group, a bipartisan panel that assessed the situation in Iraq and in 2006 made recommendations on U.S. policy there. Currently he is co-chairman of the U.S. Department of Energy’s Blue Ribbon Commission on America’s Nuclear Future. Among his published works are two books on the legislative branch-How Congress Works and Why You Should Care and Strengthening Congress. He writes twice-monthly commentaries about Congress and what individuals can do to make representative democracy work better. A leader in the growing national movement to expand and improve civic education, he serves as a Co-Chairman of the Campaign for the Civic Mission of Schools.October 26, 2011

CalabreseDr. Edward J. Calabrese is the keynote speaker on day two of the Symposium. Edward Calabrese is a Professor of Toxicology at the University of Massachusetts, School of Public Health, Amherst. Dr. Calabrese’s research includes assessment of hormesis, a dose-response concept that is characterized by low-dose stimulation and a high-dose inhibition. He traces the historical foundations of hormesis, its quantitative features and mechanistic foundations, and its risk assessment implications. It will be argued that the hormetic dose response is the most fundamental dose response, significantly out-competing other leading dose-response models in large-scale, head-to-head evaluations used by regulatory agencies such as the EPA and FDA. The hormetic dose response is highly generalizable, being independent of biological model, endpoint measured, chemical class, physical agent (e.g., radiation) and inter-individual variability. Hormesis also provides a framework for the study and assessment of chemical mixtures, incorporating the concept of additivity and synergism. Because the hormetic biphasic dose response represents a general pattern of biological responsiveness, it is expected that it will become progressively more significant within toxicological evaluation and risk assessment practices as well as having numerous biomedical applications, some of which will be emphasized in this presentation.2011 OFFICIAL SYMPOSIUM SPONSORS: